Leg ulcer with long‐term hydroxyurea use

A Hydroxyurea-induced Leg Ulcer.

Hydroxyurea is a cytostatic agent that has recently become the drug of choice in the treatment of various myeloproliferative diseases. The cutaneous side effects of hydroxyurea include xerosis, hyperpigmentation, nail discoloration, and scaling. Leg ulcers have only rarely been reported in association with hydroxyurea treatment. A 75-year-old woman presented with leg ulcers, nail discoloration,...

Hydroxyurea induced non-healing leg ulcer.

Damage to the supporting structures, disruption of the cementing substance binding the nail plate to the surrounding structures or formation of granular layer, which is otherwise absent in a normal nail bed and nail matrix, will produce onycholysis. Trauma from physical factors, manicuring, foreign body implantation or chemicals like solvents, various nail cosmetics and immersion in alkaline so...

Recurrence of hydroxyurea-induced leg ulcer after discontinuation of treatment.

Hydroxyurea associated leg ulcer succesfully treated with hyperbaric oxygen in a diabetic patient.

Oxygen tension in healing tissues is heterogeneous. Increased oxygen mostly stimulates repair mechanisms and enhances tissue healing. Hyperbaric oxygen therapy increases blood and tissue oxygen content and may help maintain cellular integrity and function. Hydroxyurea (HU) is a cytotoxic agent, which leads to inactivation of ribonucleotide reductase, inhibition of cellular DNA synthesis, and ce...

Reversible leg ulcer due to hydroxyurea in a case of chronic myeloid leukemia.

The cutaneous side effects of hydroxyurea are lesser known complication of long term hydroxyurea therapy in myeloproliferative disorders. We report a non-diabetic patient, who developed hydroxyurea dermopathy (leg ulcers) during long-term treatment with hydroxyurea for chronic myeloid leukemia (CML). The time course of the development of ulcers and its healing suggests that these resulted from ...